major drawback
potential drawback
significant drawback
Complacency is a drawback to progress.
the main drawback of fitting catalytic converters is the cost.
Slow speed is the chief drawback of sea shipment.
responsibilities that are a drawback to our pleasure;
HLA sensitization associated with previous kidney transplantation is a major drawback to retransplantation.
One of the few drawbacks to living out the boondocks is that public services, such as litter collection, are less available than they are closer to the city.
One drawback: a nonradioactive dye must be administered through the child's rectum before a CAT scan can be performed.
The greatest drawback to tricycle gear is the greater weight and drag incurred by adding the large nosewheel strut.
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